Cargando…

Studies on Synthesis and Structure-Activity Relationship (SAR) of Derivatives of a New Natural Product from Marine Fungi as Inhibitors of Influenza Virus Neuraminidase

Based on the natural isoprenyl phenyl ether from a mangrove-derived fungus, 32 analogues were synthesized and evaluated for inhibitory activity against influenza H1N1 neuraminidase. Compound 15 (3-(allyloxy)-4-hydroxybenzaldehyde) exhibited the most potent inhibitory activity, with IC(50) values of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jing, Zhang, Dingmei, Zhu, Xun, He, Zhenjian, Liu, Shu, Li, Mengfeng, Pang, Jiyan, Lin, Yongcheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210610/ https://www.ncbi.nlm.nih.gov/pubmed/22073001 http://dx.doi.org/10.3390/md9101887

Ejemplares similares

Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells
por: Chen, Hong, et al.
Publicado: (2012)

Consecutive influenza surveillance of neuraminidase mutations and neuraminidase inhibitor resistance in Japan
por: Chong, Yong, et al.
Publicado: (2019)

Design and synthesis of constrained bicyclic molecules as candidate inhibitors of influenza A neuraminidase
por: Colombo, Cinzia, et al.
Publicado: (2018)

Influenza neuraminidase
por: Air, Gillian M.
Publicado: (2011)

Systematic review of influenza resistance to the neuraminidase inhibitors
por: Thorlund, Kristian, et al.
Publicado: (2011)

The role of neuraminidase inhibitors in the treatment and prevention of influenza
por: Naem, Shahrour
Publicado: (2001)

Exploring the chemical space of influenza neuraminidase inhibitors
por: Anuwongcharoen, Nuttapat, et al.
Publicado: (2016)

Bacterial Neuraminidase Rescues Influenza Virus Replication from Inhibition by a Neuraminidase Inhibitor
por: Nishikawa, Tomoko, et al.
Publicado: (2012)

Synthesis and Biological Evaluation of NH(2)-Sulfonyl Oseltamivir Analogues as Influenza Neuraminidase Inhibitors
por: Hu, Yaping, et al.
Publicado: (2019)

Economics of Neuraminidase Inhibitor Stockpiling for Pandemic Influenza, Singapore
por: Lee, Vernon J., et al.
Publicado: (2006)

Influenza treatment and prophylaxis with neuraminidase inhibitors: a review
por: Kamali, Amanda, et al.
Publicado: (2013)

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals
por: Leang, Sook-Kwan, et al.
Publicado: (2017)

Epidemiology characteristics of respiratory viruses found in children and adults with respiratory tract infections in southern China
por: Zhang, Dingmei, et al.
Publicado: (2014)

Effects of Vaccination and the New Neuraminidase Inhibitor, Laninamivir, on Influenza Infection
por: Mizuno, Takuro, et al.
Publicado: (2014)

Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada
por: Abed, Yacine, et al.
Publicado: (2019)

Influenza Neuraminidase Inhibitors: Synthetic Approaches, Derivatives and Biological Activity
por: Laborda, Pedro, et al.
Publicado: (2016)

Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children
por: Jefferson, Tom, et al.
Publicado: (2014)

Evidence synthesis and decision modelling to support complex decisions: stockpiling neuraminidase inhibitors for pandemic influenza usage
por: Watson, Samuel I., et al.
Publicado: (2017)

Natural Products from Marine Fungi
por: Shin, Hee Jae
Publicado: (2020)

A neuraminidase potency assay for quantitative assessment of neuraminidase in influenza vaccines
por: Byrne-Nash, Rose T., et al.
Publicado: (2019)

Aurintricarboxylic acid inhibits influenza virus neuraminidase
por: Hung, Hui-Chen, et al.
Publicado: (2009)

Neuraminidase inhibitor susceptibility and neuraminidase enzyme kinetics of human influenza A and B viruses circulating in Thailand in 2010–2015
por: Tewawong, Nipaporn, et al.
Publicado: (2018)

Aurintricarboxylic Acid Is a Potent Inhibitor of Influenza A and B Virus Neuraminidases
por: Hashem, Anwar M., et al.
Publicado: (2009)

A Marine Anthraquinone SZ-685C Overrides Adriamycin-Resistance in Breast Cancer Cells through Suppressing Akt Signaling
por: Zhu, Xun, et al.
Publicado: (2012)

Structure-based design of 5′-substituted 1,2,3-triazolylated oseltamivir derivatives as potent influenza neuraminidase inhibitors
por: Wang, Pengfei, et al.
Publicado: (2021)

Identification of Chebulinic Acid and Chebulagic Acid as Novel Influenza Viral Neuraminidase Inhibitors
por: Li, Ping, et al.
Publicado: (2020)

Neuraminidase Inhibitor Resistance in Influenza: Assessing the Danger of Its Generation and Spread
por: Handel, Andreas, et al.
Publicado: (2007)

Effectiveness of Neuraminidase Inhibitors for Preventing Staff Absenteeism during Pandemic Influenza
por: Lee, Vernon J., et al.
Publicado: (2007)

Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses†
por: Oakley, Aaron J., et al.
Publicado: (2010)

Structural basis for a class of nanomolar influenza A neuraminidase inhibitors
por: Kerry, Philip S., et al.
Publicado: (2013)

Contribution of Neuraminidase of Influenza Viruses to the Sensitivity to Sera Inhibitors and Reassortment Efficiency
por: Kiseleva, Irina, et al.
Publicado: (2014)

Susceptibility of influenza viruses circulating in Western Saudi Arabia to neuraminidase inhibitors
por: Tolah, Ahmed M., et al.
Publicado: (2016)

Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study
por: Higa, Futoshi, et al.
Publicado: (2011)

Neuraminidase Inhibitors in Influenza Treatment and Prevention–Is It Time to Call It a Day?
por: Parra-Rojas, César, et al.
Publicado: (2018)

Characterization of Influenza B Virus Variants with Reduced Neuraminidase Inhibitor Susceptibility
por: Farrukee, R., et al.
Publicado: (2018)

Effectiveness of four types of neuraminidase inhibitors approved in Japan for the treatment of influenza
por: Mawatari, Momoko, et al.
Publicado: (2019)

Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design
por: Zhu, Qinchang, et al.
Publicado: (2015)

The Neglected Marine Fungi, Sensu stricto, and Their Isolation for Natural Products’ Discovery
por: Overy, David P., et al.
Publicado: (2019)

Mechanism of 150-cavity formation in influenza neuraminidase
por: Amaro, Rommie E., et al.
Publicado: (2011)

Influenza Virus Neuraminidase: Structure and Function
por: Shtyrya, Y.A., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_fcrpiuth102595pofe0b6h2oqh