Hedgehog Signaling Antagonist GDC-0449 (Vismodegib) Inhibits Pancreatic Cancer Stem Cell Characteristics: Molecular Mechanisms

BACKGROUND: Recent evidence from in vitro and in vivo studies has demonstrated that aberrant reactivation of the Sonic Hedgehog (SHH) signaling pathway regulates genes that promote cellular proliferation in various human cancer stem cells (CSCs). Therefore, the chemotherapeutic agents that inhibit a...

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Detalles Bibliográficos
Autores principales: Singh, Brahma N., Fu, Junsheng, Srivastava, Rakesh K., Shankar, Sharmila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210776/
https://www.ncbi.nlm.nih.gov/pubmed/22087285
http://dx.doi.org/10.1371/journal.pone.0027306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210776/
https://www.ncbi.nlm.nih.gov/pubmed/22087285
http://dx.doi.org/10.1371/journal.pone.0027306

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