Cargando…

High Glucose Promotes Pancreatic Cancer Cell Proliferation via the Induction of EGF Expression and Transactivation of EGFR

Multiple lines of evidence suggest that a large portion of pancreatic cancer patients suffer from either hyperglycemia or diabetes, both of which are characterized by high blood glucose level. However, the underlying biological mechanism of this phenomenon is largely unknown. In the present study, w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Liang, Ma, Qingyong, Li, Junhui, Liu, Han, Li, Wei, Ma, Guodong, Xu, Qinhong, Zhou, Shuang, Wu, Erxi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210779/ https://www.ncbi.nlm.nih.gov/pubmed/22087246 http://dx.doi.org/10.1371/journal.pone.0027074

Ejemplares similares

Relationship between Neural Alteration and Perineural Invasion in Pancreatic Cancer Patients with Hyperglycemia
por: Li, Junhui, et al.
Publicado: (2011)

Hydrogen peroxide mediates hyperglycemia-induced invasive activity via ERK and p38 MAPK in human pancreatic cancer
por: Li, Wei, et al.
Publicado: (2015)

Hyperglycemia aggravates microenvironment hypoxia and promotes the metastatic ability of pancreatic cancer
por: Li, Wei, et al.
Publicado: (2018)

Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner
por: Lei, Jianjun, et al.
Publicado: (2013)

Pancreatic stellate cells contribute pancreatic cancer pain via activation of sHH signaling pathway
por: Han, Liang, et al.
Publicado: (2016)

Stromal-derived factor-1α/CXCL12-CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer
por: Xu, Qinhong, et al.
Publicado: (2014)

Overexpression of Nodal induces a metastatic phenotype in pancreatic cancer cells via the Smad2/3 pathway
por: Duan, Wanxing, et al.
Publicado: (2015)

HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats
por: Maachi, Hasna, et al.
Publicado: (2020)

Cav-1 Ablation in Pancreatic Stellate Cells Promotes Pancreatic Cancer Growth through Nrf2-Induced shh Signaling
por: Shao, Shan, et al.
Publicado: (2020)

α-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3K/Akt Pathway
por: Xu, Qinhong, et al.
Publicado: (2014)

The bidirectional interation between pancreatic cancer and diabetes
por: Li, Junhui, et al.
Publicado: (2012)

NAF-1 Inhibition by Resveratrol Suppresses Cancer Stem Cell-Like Properties and the Invasion of Pancreatic Cancer
por: Qin, Tao, et al.
Publicado: (2020)

EGF Functionalized Polymer-Coated Gold Nanoparticles Promote EGF Photostability and EGFR Internalization for Photothermal Therapy
por: Silva, Catarina Oliveira, et al.
Publicado: (2016)

Hyperglycemia, a Neglected Factor during Cancer Progression
por: Duan, Wanxing, et al.
Publicado: (2014)

EGF stimulates glioblastoma metastasis by induction of matrix metalloproteinase-9 in an EGFR-dependent mechanism
por: Chen, Xing-Chen, et al.
Publicado: (2017)

Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway
por: Sheng, Weiwei, et al.
Publicado: (2017)

EGFR transactivates RON to drive oncogenic crosstalk
por: Franco Nitta, Carolina, et al.
Publicado: (2021)

LncRNA ARAP1‐AS2 promotes high glucose‐induced human proximal tubular cell injury via persistent transactivation of the EGFR by interacting with ARAP1
por: Li, Xin, et al.
Publicado: (2020)

miR-21 promotes EGF-induced pancreatic cancer cell proliferation by targeting Spry2
por: Zhao, Qiuyan, et al.
Publicado: (2018)

EBP50 inhibits EGF-induced breast cancer cell proliferation by blocking EGFR phosphorylation
por: Yao, Wenfang, et al.
Publicado: (2012)

EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development
por: Cheng, Zhe, et al.
Publicado: (2017)

Editorial: The Microenvironment in Pancreatic Cancer and Therapeutic Strategies Targeting Microenvironment
por: Duan, Wanxing, et al.
Publicado: (2022)

Brk/PTK6 Sustains Activated EGFR Signaling through Inhibiting EGFR Degradation and Transactivating EGFR
por: Li, X, et al.
Publicado: (2012)

The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer
por: Qian, Weikun, et al.
Publicado: (2021)

β(2)-Adrenogenic signaling regulates NNK-induced pancreatic cancer progression via upregulation of HIF-1α
por: Zhang, Dong, et al.
Publicado: (2015)

Sonic Hedgehog modulates EGFR dependent proliferation of neural stem cells during late mouse embryogenesis through EGFR transactivation
por: Reinchisi, Gisela, et al.
Publicado: (2013)

The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein–coupled receptors
por: Yan, Yibing, et al.
Publicado: (2002)

The Silkworm Carboxypeptidase Inhibitor Prevents Gastric Cancer Cells’ Proliferation through the EGF/EGFR Signaling Pathway
por: Ye, Junhong, et al.
Publicado: (2023)

Betulinic acid inhibits stemness and EMT of pancreatic cancer cells via activation of AMPK signaling
por: Sun, Liankang, et al.
Publicado: (2018)

Rapamycin Induces Transactivation of the EGFR and Increases Cell Survival
por: Chaturvedi, Deepti, et al.
Publicado: (2009)

EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis
por: Yang, Xiao-Pei, et al.
Publicado: (2016)

Genetic variations in EGF and EGFR and glioblastoma outcome
por: Sjöström, Sara, et al.
Publicado: (2010)

Sorcin promotes migration in cancer and regulates the EGF-dependent EGFR signaling pathways
por: Tito, Claudia, et al.
Publicado: (2023)

Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-κB signaling
por: Liu, Jiangbo, et al.
Publicado: (2014)

Neurokinin-1 receptor promotes non-small cell lung cancer progression through transactivation of EGFR
por: Zhang, Xiao-Wei, et al.
Publicado: (2022)

GPR54 (KISS1R) Transactivates EGFR to Promote Breast Cancer Cell Invasiveness
por: Zajac, Mateusz, et al.
Publicado: (2011)

Transactivation of EGFR by LPS Induces COX-2 Expression in Enterocytes
por: McElroy, Steven J., et al.
Publicado: (2012)

Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation
por: Schlange, Thomas, et al.
Publicado: (2007)

Hypoxic‐induction of arginase II requires EGF‐mediated EGFR activation in human pulmonary microvascular endothelial cells
por: Pool, Caitlyn M., et al.
Publicado: (2018)

The EGF/EGFR axis and its downstream signaling pathways regulate the motility and proliferation of cultured oral keratinocytes
por: Kobayashi, Ryota, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lttg6qd3juekmiqif4cnceq64d