AF17 Facilitates Dot1a Nuclear Export and Upregulates ENaC-Mediated Na+ Transport in Renal Collecting Duct Cells

Our previous work in 293T cells and AF17(-/-) mice suggests that AF17 upregulates expression and activity of the epithelial Na(+) channel (ENaC), possibly by relieving Dot1a-AF9-mediated repression. However, whether and how AF17 directly regulates Dot1a cellular distribution and ENaC function in ren...

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Detalles Bibliográficos
Autores principales: Wu, Hongyu, Chen, Lihe, Zhou, Qiaoling, Zhang, Wenzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210795/
https://www.ncbi.nlm.nih.gov/pubmed/22087315
http://dx.doi.org/10.1371/journal.pone.0027429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210795/
https://www.ncbi.nlm.nih.gov/pubmed/22087315
http://dx.doi.org/10.1371/journal.pone.0027429

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