Tissue factor-PAR2 signaling promotes diet-induced obesity and adipose inflammation

Tissue factor (TF), the initiator of the coagulation cascade, mediates coagulation factor VIIa-dependent activation of protease activated receptor-2 (PAR2). Here we delineate an unexpected role for coagulation signaling in obesity and its complications. Mice lacking PAR2 (F2rl1) or the cytoplasmic d...

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Detalles Bibliográficos
Autores principales: Badeanlou, Leylla, Furlan-Freguia, Christian, Yang, Guang, Ruf, Wolfram, Samad, Fahumiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210891/
https://www.ncbi.nlm.nih.gov/pubmed/22019885
http://dx.doi.org/10.1038/nm.2461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210891/
https://www.ncbi.nlm.nih.gov/pubmed/22019885
http://dx.doi.org/10.1038/nm.2461

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