Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3-dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery

1,3-Dicyclohexylurea (DCU), a potent soluble epoxide hydrolase (sEH) inhibitor has been reported to lower systemic blood pressure in spontaneously hypertensive rats. One limitation of continual administration of DCU for in vivo studies is the compound's poor oral bioavailability. This phenomeno...

Descripción completa

Detalles Bibliográficos
Autores principales: Chiang, Po-Chang, Ran, Yingqing, Chou, Kang-Jye, Cui, Yong, Wong, Harvey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2011
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3211509/
https://www.ncbi.nlm.nih.gov/pubmed/21711942
http://dx.doi.org/10.1186/1556-276X-6-413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3211509/
https://www.ncbi.nlm.nih.gov/pubmed/21711942
http://dx.doi.org/10.1186/1556-276X-6-413

Ejemplares similares