A Convenient Model of Severe, High Incidence Autoimmune Gastritis Caused by Polyclonal Effector T Cells and without Perturbation of Regulatory T Cells

Autoimmune gastritis results from the breakdown of T cell tolerance to the gastric H(+)/K(+) ATPase. The gastric H(+)/K(+) ATPase is responsible for the acidification of gastric juice and consists of an α subunit (H/Kα) and a β subunit (H/Kβ). Here we show that CD4(+) T cells from H/Kα-deficient mic...

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Detalles Bibliográficos
Autores principales: Tu, Eric, Ang, Desmond K. Y., Hogan, Thea V., Read, Simon, Chia, Cheryl P. Z., Gleeson, Paul A., van Driel, Ian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212540/
https://www.ncbi.nlm.nih.gov/pubmed/22096532
http://dx.doi.org/10.1371/journal.pone.0027153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212540/
https://www.ncbi.nlm.nih.gov/pubmed/22096532
http://dx.doi.org/10.1371/journal.pone.0027153

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