Loss of Sphingosine Kinase 1/S1P Signaling Impairs Cell Growth and Survival of Neurons and Progenitor Cells in the Developing Sensory Ganglia

BACKGROUND: Lysophospholipids such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are important signaling molecules that can regulate a wide range of cellular responses. We discovered that Sphingosine kinase 1 (Sphk1), a key enzyme that converts sphingosine to S1P, is expressed in...

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Detalles Bibliográficos
Autores principales: Meng, Hui, Yuan, Yuan, Lee, Vivian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212543/
https://www.ncbi.nlm.nih.gov/pubmed/22096531
http://dx.doi.org/10.1371/journal.pone.0027150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212543/
https://www.ncbi.nlm.nih.gov/pubmed/22096531
http://dx.doi.org/10.1371/journal.pone.0027150

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