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Non-alcoholic fatty liver disease and correlation of serum alanin aminotransferase level with histopathologic findings

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has been recognized as the most common cause of chronic liver disease worldwide. It occurs in patients who do not consume alcohol in large amounts. Alanine aminotranferase (ALT) and aspartate aminotransferase (AST) are indicators of hepatocellula...

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Autores principales: Khosravi, Somaye, Alavian, Seyed Moayed, Zare, Ali, Daryani, Nasser Ebrahimi, Fereshtehnejad, Seyed-Mohammad, Daryani, Narges Ebrahimi, Keramati, Mohammad Reza, Abdollahzade, Sina, Taba taba Vakili, Sahar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212791/
https://www.ncbi.nlm.nih.gov/pubmed/22087177
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author Khosravi, Somaye
Alavian, Seyed Moayed
Zare, Ali
Daryani, Nasser Ebrahimi
Fereshtehnejad, Seyed-Mohammad
Daryani, Narges Ebrahimi
Keramati, Mohammad Reza
Abdollahzade, Sina
Taba taba Vakili, Sahar
author_facet Khosravi, Somaye
Alavian, Seyed Moayed
Zare, Ali
Daryani, Nasser Ebrahimi
Fereshtehnejad, Seyed-Mohammad
Daryani, Narges Ebrahimi
Keramati, Mohammad Reza
Abdollahzade, Sina
Taba taba Vakili, Sahar
author_sort Khosravi, Somaye
collection PubMed
description BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has been recognized as the most common cause of chronic liver disease worldwide. It occurs in patients who do not consume alcohol in large amounts. Alanine aminotranferase (ALT) and aspartate aminotransferase (AST) are indicators of hepatocellular injury. OBJECTIVES: To determine correlation between histopathologic specifications of NAFLD in patients with little or no history of alcohol consumption and the serum level of ALT. PATIENTS AND METHODS: In a cross-sectional study carried out in two gastroenterology and hepatology clinics in Tehran, Iran, the medical records of those who had undergone liver biopsies between years 2005 and 2009 were reviewed. Clinical and laboratory information of biopsy-proven cases of NAFLD were obtained from 147 eligible medical records. The histopathologic, demographic, and laboratory data of the participants were also collected. Two groups of patients according to their serum ALT level (cut-point of 35 U/L) were defined. The quantitative pathologic grade of the biopsy specimens was determined based on Brunt scoring system. RESULTS: We studied 147 NAFLD patients including 127 men (86.4%) and 20 women (13.6%) with a mean ± SD age of 41.4 ± 11.2 years. Considering serum ALT, the mean ± SD quantitative grade of hepatosteatosis was 1.50 ± 0.67 and 1.74 ± 0.73 (p=0.136); advanced fibrosis (consisted of grade III and cirrhosis) was found in 4.5% (1/22) and 5.6% (7/125) of patients (p=0.327). CONCLUSIONS: We found that using the cut-off value of 35 U/L for serum ALT level, it has little contribution to predict NAFLD severity.
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spelling pubmed-32127912011-11-15 Non-alcoholic fatty liver disease and correlation of serum alanin aminotransferase level with histopathologic findings Khosravi, Somaye Alavian, Seyed Moayed Zare, Ali Daryani, Nasser Ebrahimi Fereshtehnejad, Seyed-Mohammad Daryani, Narges Ebrahimi Keramati, Mohammad Reza Abdollahzade, Sina Taba taba Vakili, Sahar Hepat Mon Original Article BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has been recognized as the most common cause of chronic liver disease worldwide. It occurs in patients who do not consume alcohol in large amounts. Alanine aminotranferase (ALT) and aspartate aminotransferase (AST) are indicators of hepatocellular injury. OBJECTIVES: To determine correlation between histopathologic specifications of NAFLD in patients with little or no history of alcohol consumption and the serum level of ALT. PATIENTS AND METHODS: In a cross-sectional study carried out in two gastroenterology and hepatology clinics in Tehran, Iran, the medical records of those who had undergone liver biopsies between years 2005 and 2009 were reviewed. Clinical and laboratory information of biopsy-proven cases of NAFLD were obtained from 147 eligible medical records. The histopathologic, demographic, and laboratory data of the participants were also collected. Two groups of patients according to their serum ALT level (cut-point of 35 U/L) were defined. The quantitative pathologic grade of the biopsy specimens was determined based on Brunt scoring system. RESULTS: We studied 147 NAFLD patients including 127 men (86.4%) and 20 women (13.6%) with a mean ± SD age of 41.4 ± 11.2 years. Considering serum ALT, the mean ± SD quantitative grade of hepatosteatosis was 1.50 ± 0.67 and 1.74 ± 0.73 (p=0.136); advanced fibrosis (consisted of grade III and cirrhosis) was found in 4.5% (1/22) and 5.6% (7/125) of patients (p=0.327). CONCLUSIONS: We found that using the cut-off value of 35 U/L for serum ALT level, it has little contribution to predict NAFLD severity. Kowsar 2011-06-01 2011-06-01 /pmc/articles/PMC3212791/ /pubmed/22087177 Text en Copyright © 2011, Kowsar M.P. Co. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Khosravi, Somaye
Alavian, Seyed Moayed
Zare, Ali
Daryani, Nasser Ebrahimi
Fereshtehnejad, Seyed-Mohammad
Daryani, Narges Ebrahimi
Keramati, Mohammad Reza
Abdollahzade, Sina
Taba taba Vakili, Sahar
Non-alcoholic fatty liver disease and correlation of serum alanin aminotransferase level with histopathologic findings
title Non-alcoholic fatty liver disease and correlation of serum alanin aminotransferase level with histopathologic findings
title_full Non-alcoholic fatty liver disease and correlation of serum alanin aminotransferase level with histopathologic findings
title_fullStr Non-alcoholic fatty liver disease and correlation of serum alanin aminotransferase level with histopathologic findings
title_full_unstemmed Non-alcoholic fatty liver disease and correlation of serum alanin aminotransferase level with histopathologic findings
title_short Non-alcoholic fatty liver disease and correlation of serum alanin aminotransferase level with histopathologic findings
title_sort non-alcoholic fatty liver disease and correlation of serum alanin aminotransferase level with histopathologic findings
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212791/
https://www.ncbi.nlm.nih.gov/pubmed/22087177
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