Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity

[Image: see text] Apratoxins are cytotoxic marine natural products that prevent cotranslational translocation early in the secretory pathway. We showed that apratoxins downregulate receptors and growth factor ligands, giving a one–two punch to cancer cells, particularly those that rely on autocrine...

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Detalles Bibliográficos
Autores principales: Chen, Qi-Yin, Liu, Yanxia, Luesch, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212850/
https://www.ncbi.nlm.nih.gov/pubmed/22081789
http://dx.doi.org/10.1021/ml200176m

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212850/
https://www.ncbi.nlm.nih.gov/pubmed/22081789
http://dx.doi.org/10.1021/ml200176m

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