Cargando…
Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity
[Image: see text] Apratoxins are cytotoxic marine natural products that prevent cotranslational translocation early in the secretory pathway. We showed that apratoxins downregulate receptors and growth factor ligands, giving a one–two punch to cancer cells, particularly those that rely on autocrine...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2011
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212850/ https://www.ncbi.nlm.nih.gov/pubmed/22081789 http://dx.doi.org/10.1021/ml200176m |