Cargando…

The evolution of pyrimethamine resistant dhfr in Plasmodium falciparum of south-eastern Tanzania: comparing selection under SP alone vs SP+artesunate combination

BACKGROUND: Sulphadoxine-pyrimethamine (SP) resistance is now widespread throughout east and southern Africa and artemisinin compounds in combination with synthetic drugs (ACT) are recommended as replacement treatments by the World Health Organization (WHO). As well as high cure rates, ACT has been...

Descripción completa

Detalles Bibliográficos
Autores principales:	Malisa, Allen L, Pearce, Richard J, Mutayoba, Ben M, Abdullah, Salim, Mshinda, Hassan, Kachur, Patrick S, Bloland, Peter, Roper, Cally
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213132/ https://www.ncbi.nlm.nih.gov/pubmed/22029848 http://dx.doi.org/10.1186/1475-2875-10-317

Ejemplares similares

The genetic change in P. falciparum populations of rural Tanzania resulting from national policy on firstline malaria treatment and pilot Sulfadoxine/pyrimethamine and Artesunate combination
por: Malisa, Allen, et al.
Publicado: (2010)

Drug coverage in treatment of malaria and the consequences for resistance evolution - evidence from the use of sulphadoxine/pyrimethamine
por: Malisa, Allen L, et al.
Publicado: (2010)

Drug resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum malaria in Mlimba, Tanzania
por: Mbugi, Erasto V, et al.
Publicado: (2006)

Media, Health Workers, and Policy Makers' Relationship and Their Impact on Antimalarial Policy Adoption: A Population Genetics Perspective
por: Malisa, Allen, et al.
Publicado: (2011)

Molecular monitoring of Plasmodium falciparum super-resistance to sulfadoxine–pyrimethamine in Tanzania
por: Kavishe, Reginald A., et al.
Publicado: (2016)

Efficacy of Artesunate + Sulphadoxine-Pyrimethamine (AS + SP) and Amodiaquine + Sulphadoxine-Pyrimethamine (AQ + SP) for Uncomplicated falciparum Malaria in Equatorial Guinea (Central Africa)
por: Charle, Pilar, et al.
Publicado: (2009)

Efficacy of sulphadoxine-pyrimethamine + artesunate, sulphadoxine-pyrimethamine + amodiaquine, and sulphadoxine-pyrimethamine alone in uncomplicated falciparum malaria in Mali
por: Maiga, Hamma, et al.
Publicado: (2015)

In vitro susceptibility to pyrimethamine of DHFR I164L single mutant Plasmodium falciparum
por: Andriantsoanirina, Valérie, et al.
Publicado: (2011)

Mapping sulphadoxine-pyrimethamine-resistant Plasmodium falciparum malaria in infected humans and in parasite populations in Africa
por: Okell, Lucy C., et al.
Publicado: (2017)

Randomized Trial of Artesunate+Amodiaquine, Sulfadoxine-Pyrimethamine+Amodiaquine, Chlorproguanal-Dapsone and SP for Malaria in Pregnancy in Tanzania
por: Mutabingwa, Theonest K., et al.
Publicado: (2009)

Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan
por: Elamin, Sakina B, et al.
Publicado: (2005)

High Resistance of Plasmodium falciparum to Sulphadoxine/Pyrimethamine in Northern Tanzania and the Emergence of dhps Resistance Mutation at Codon 581
por: Gesase, Samwel, et al.
Publicado: (2009)

Primaquine Clears Submicroscopic Plasmodium falciparum Gametocytes that Persist after Treatment with Sulphadoxine-Pyrimethamine and Artesunate
por: Shekalaghe, Seif, et al.
Publicado: (2007)

Polymorphism in dhfr/dhps genes, parasite density and ex vivo response to pyrimethamine in Plasmodium falciparum malaria parasites in Thies, Senegal()
por: Ndiaye, Daouda, et al.
Publicado: (2013)

Plasmodium vivax dhfr and dhps mutations in isolates from Madagascar and therapeutic response to sulphadoxine-pyrimethamine
por: Barnadas, Céline, et al.
Publicado: (2008)

Characterizing the impact of sustained sulfadoxine/pyrimethamine use upon the Plasmodium falciparum population in Malawi
por: Ravenhall, Matt, et al.
Publicado: (2016)

High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children
por: Mombo-Ngoma, Ghyslain, et al.
Publicado: (2011)

Rapid increase of Plasmodium falciparum dhfr/dhps resistant haplotypes, after the adoption of sulphadoxine-pyrimethamine as first line treatment in 2002, in southern Mozambique
por: Enosse, Sonia, et al.
Publicado: (2008)

Low risk of recurrence following artesunate–Sulphadoxine–pyrimethamine plus primaquine for uncomplicated Plasmodium falciparum and Plasmodium vivax infections in the Republic of the Sudan
por: Hamid, Muzamil Mahdi Abdel, et al.
Publicado: (2018)

Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana
por: Mockenhaupt, Frank P, et al.
Publicado: (2005)

Molecular determinants of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum in Nigeria and the regional emergence of dhps 431V
por: Oguike, Mary C., et al.
Publicado: (2016)

Declining trend of Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant alleles after the withdrawal of Sulfadoxine-Pyrimethamine in North Western Ethiopia
por: Tessema, Sofonias K., et al.
Publicado: (2015)

Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania
por: Mugittu, Kefas, et al.
Publicado: (2006)

High-level Plasmodium falciparum sulfadoxine-pyrimethamine resistance with the concomitant occurrence of septuple haplotype in Tanzania
por: Baraka, Vito, et al.
Publicado: (2015)

Efficacy of sulphadoxine-pyrimethamine with or without artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in southern Mozambique: a randomized controlled trial
por: Allen, Elizabeth N, et al.
Publicado: (2009)

Clinical trials of artesunate plus sulfadoxine-pyrimethamine for Plasmodium falciparum malaria in Afghanistan: maintained efficacy a decade after introduction
por: Awab, Ghulam Rahim, et al.
Publicado: (2016)

A fixed-dose 24-hour regimen of artesunate plus sulfamethoxypyrazine-pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in eastern Sudan
por: Adam, Ishag, et al.
Publicado: (2006)

Efficacy and safety of artemether + lumefantrine, artesunate + sulphamethoxypyrazine-pyrimethamine and artesunate + amodiaquine and sulphadoxine-pyrimethamine + amodiaquine in the treatment of uncomplicated falciparum malaria in Bangui, Central African Republic: a randomized trial
por: Djallé, Djibrine, et al.
Publicado: (2014)

Independent Origin of Plasmodium falciparum Antifolate Super-Resistance, Uganda, Tanzania, and Ethiopia
por: Alifrangis, Michael, et al.
Publicado: (2014)

Temporal trends of sulphadoxine-pyrimethamine (SP) drug-resistance molecular markers in Plasmodium falciparum parasites from pregnant women in western Kenya
por: Iriemenam, Nnaemeka C, et al.
Publicado: (2012)

MOLECULAR SURVEILLANCE OF Plasmodium vivax AND Plasmodium falciparum DHFR MUTATIONS IN ISOLATES FROM SOUTHERN IRAN
por: SHARIFI-SARASIABI, Khojasteh, et al.
Publicado: (2016)

Decreased availability of antimalarials in the private sector following the policy change from chloroquine to sulphadoxine-pyrimethamine in the Kilombero Valley, Tanzania
por: Hetzel, Manuel W, et al.
Publicado: (2006)

A snapshot of the prevalence of dihydropteroate synthase-431V mutation and other sulfadoxine-pyrimethamine resistance markers in Plasmodium falciparum isolates in Nigeria
por: Adegbola, Adebanjo J., et al.
Publicado: (2023)

Defining Plasmodium falciparum Treatment in South West Asia: A Randomized Trial Comparing Artesunate or Primaquine Combined with Chloroquine or SP
por: Kolaczinski, Kate, et al.
Publicado: (2012)

Selection of pfdhfr/pfdhps alleles and declining artesunate/sulphadoxine-pyrimethamine efficacy against Plasmodium falciparum eight years after deployment in eastern Sudan
por: Gadalla, Nahla B, et al.
Publicado: (2013)

Sustained efficacy of artesunate-sulfadoxine-pyrimethamine against Plasmodium falciparum in Yemen and a renewed call for an adjunct single dose primaquine to clear gametocytes
por: Atroosh, Wahib M., et al.
Publicado: (2016)

Trends in Molecular Markers Associated with Resistance to Sulfadoxine-Pyrimethamine (SP) Among Plasmodium falciparum Isolates on Bioko Island, Equatorial Guinea: 2011–2017
por: Lin, Li-Yun, et al.
Publicado: (2020)

Surveillance of artemether-lumefantrine associated Plasmodium falciparum multidrug resistance protein-1 gene polymorphisms in Tanzania
por: Kavishe, Reginald A, et al.
Publicado: (2014)

Effectiveness of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine in Pregnancy: Low Coverage and High Prevalence of Plasmodium falciparum dhfr-dhps Quintuple Mutants as Major Challenges in Douala, an Urban Setting in Cameroon
por: Eboumbou Moukoko, Carole Else, et al.
Publicado: (2023)

Slipknot or Crystallographic Error: A Computational Analysis of the Plasmodium falciparum DHFR Structural Folds
por: Tata, Rolland B., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ja8q3paonsrvq3oqoig77he15f