Ago-2-Mediated Slicer Activity Is Essential for Anti-Flaviviral Efficacy of RNAi

RNA interference can be mediated by fully complementary siRNA or partially complementary miRNA. siRNAs are widely used to suppress viral replication and the fully complementary siRNA bound Ago-2 in the RISC is known to degrade the target RNA. Although other argonaute proteins lacking slicer activity...

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Detalles Bibliográficos
Autores principales: Chen, Shuiping, Chahar, Harendra S., Abraham, Sojan, Wu, Haoquan, Pierson, Theodore C., Wang, Xiaozhong A., Manjunath, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213142/
https://www.ncbi.nlm.nih.gov/pubmed/22102908
http://dx.doi.org/10.1371/journal.pone.0027551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213142/
https://www.ncbi.nlm.nih.gov/pubmed/22102908
http://dx.doi.org/10.1371/journal.pone.0027551

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