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Ago-2-Mediated Slicer Activity Is Essential for Anti-Flaviviral Efficacy of RNAi
RNA interference can be mediated by fully complementary siRNA or partially complementary miRNA. siRNAs are widely used to suppress viral replication and the fully complementary siRNA bound Ago-2 in the RISC is known to degrade the target RNA. Although other argonaute proteins lacking slicer activity...
Autores principales: | Chen, Shuiping, Chahar, Harendra S., Abraham, Sojan, Wu, Haoquan, Pierson, Theodore C., Wang, Xiaozhong A., Manjunath, N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213142/ https://www.ncbi.nlm.nih.gov/pubmed/22102908 http://dx.doi.org/10.1371/journal.pone.0027551 |
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