Systemic Autoimmunity and Lymphoproliferation Are Associated with Excess IL-7 and Inhibited by IL-7Rα Blockade

Lupus is characterized by disturbances in lymphocyte homeostasis, as demonstrated by the marked accumulation of activated/memory T cells. Here, we provide evidence that proliferation of the CD8(+) precursors for the accumulating CD4(–)CD8(–) T cells in MRL-Fas(lpr) lupus-predisposed mice is, in part...

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Detalles Bibliográficos
Autores principales: Gonzalez-Quintial, Rosana, Lawson, Brian R., Scatizzi, John C., Craft, Joseph, Kono, Dwight H., Baccala, Roberto, Theofilopoulos, Argyrios N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213145/
https://www.ncbi.nlm.nih.gov/pubmed/22102903
http://dx.doi.org/10.1371/journal.pone.0027528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213145/
https://www.ncbi.nlm.nih.gov/pubmed/22102903
http://dx.doi.org/10.1371/journal.pone.0027528

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