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Consequences of Eukaryotic Enhancer Architecture for Gene Expression Dynamics, Development, and Fitness

The regulatory logic of time- and tissue-specific gene expression has mostly been dissected in the context of the smallest DNA fragments that, when isolated, recapitulate native expression in reporter assays. It is not known if the genomic sequences surrounding such fragments, often evolutionarily c...

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Detalles Bibliográficos
Autores principales: Ludwig, Michael Z., Manu, Kittler, Ralf, White, Kevin P., Kreitman, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213169/
https://www.ncbi.nlm.nih.gov/pubmed/22102826
http://dx.doi.org/10.1371/journal.pgen.1002364