Substrate-Favored Lysosomal and Proteasomal Pathways Participate in the Normal Balance Control of Insulin Precursor Maturation and Disposal in β-Cells

Our recent studies have uncovered that aggregation-prone proinsulin preserves a low relative folding rate and maintains a homeostatic balance of natively and non-natively folded states (i.e., proinsulin homeostasis, PIHO) in β-cells as a result of the integration of maturation and disposal processes...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaoping, Yuan, Qingxin, Tang, Wei, Gu, Jingyu, Osei, Kwame, Wang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213186/
https://www.ncbi.nlm.nih.gov/pubmed/22102916
http://dx.doi.org/10.1371/journal.pone.0027647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213186/
https://www.ncbi.nlm.nih.gov/pubmed/22102916
http://dx.doi.org/10.1371/journal.pone.0027647

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