Cargando…

Substrate-Favored Lysosomal and Proteasomal Pathways Participate in the Normal Balance Control of Insulin Precursor Maturation and Disposal in β-Cells

Our recent studies have uncovered that aggregation-prone proinsulin preserves a low relative folding rate and maintains a homeostatic balance of natively and non-natively folded states (i.e., proinsulin homeostasis, PIHO) in β-cells as a result of the integration of maturation and disposal processes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xiaoping, Yuan, Qingxin, Tang, Wei, Gu, Jingyu, Osei, Kwame, Wang, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213186/ https://www.ncbi.nlm.nih.gov/pubmed/22102916 http://dx.doi.org/10.1371/journal.pone.0027647

Ejemplares similares

Control of Precursor Maturation and Disposal Is an Early Regulative Mechanism in the Normal Insulin Production of Pancreatic β-Cells
por: Wang, Jie, et al.
Publicado: (2011)

Proinsulin Atypical Maturation and Disposal Induces Extensive Defects in Mouse Ins2(+/Akita) β-Cells
por: Yuan, Qingxin, et al.
Publicado: (2012)

ESCRTing proteasomes to the lysosome
por: Segev, Nava
Publicado: (2020)

Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing
por: Evrard, Caroline, et al.
Publicado: (2018)

Axenic Culture of Caenorhabditis elegans Alters Lysosomal/Proteasomal Balance and Increases Neuropeptide Expression
por: Cai, Huaihan, et al.
Publicado: (2022)

Adaptation of Proteasomes and Lysosomes to Cellular Environments
por: Mebratu, Yohannes Afework, et al.
Publicado: (2020)

Effects of ammonia on processing and secretion of precursor and mature lysosomal enzyme from macrophages of normal and pale ear mice: evidence for two distinct pathways
Publicado: (1985)

Proteasome in action: substrate degradation by the 26S proteasome
por: Sahu, Indrajit, et al.
Publicado: (2021)

Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively
por: Donnellan, Peter D, et al.
Publicado: (2009)

The ATP/Mg(2+) Balance Affects the Degradation of Short Fluorogenic Substrates by the 20S Proteasome
por: Morozov, Alexey, et al.
Publicado: (2022)

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
por: Thompson, Leslie Michels, et al.
Publicado: (2009)

IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin
por: Chiang, Wei-Chieh, et al.
Publicado: (2012)

Proteasomal and lysosomal degradation for specific and durable suppression of immunotherapeutic targets
por: Wang, Yungang, et al.
Publicado: (2020)

BACE2 degradation is mediated by both the proteasome and lysosome pathways
por: Qiu, Kaixin, et al.
Publicado: (2020)

Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates
por: Sandu, Cristinel, et al.
Publicado: (2015)

Cooperativity in Proteasome Core Particle Maturation
por: Suppahia, Anjana, et al.
Publicado: (2020)

Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome()()
por: Sandri, Marco
Publicado: (2013)

The Role of Ubiquitin-Proteasome Pathway and Autophagy-Lysosome Pathway in Cerebral Ischemia
por: Chen, Chunli, et al.
Publicado: (2020)

COVID-19 disposable face masks: a precursor for synthesis of valuable bioproducts
por: Oginni, Oluwatosin
Publicado: (2021)

Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils
por: Noack, Andreas, et al.
Publicado: (2018)

Elevation of Proteasomal Substrate Levels Sensitizes Cells to Apoptosis Induced by Inhibition of Proteasomal Deubiquitinases
por: Sun, Chao, et al.
Publicado: (2014)

Organic flash memory on various flexible substrates for foldable and disposable electronics
por: Lee, Seungwon, et al.
Publicado: (2017)

Macropinosome maturation and fusion with tubular lysosomes in macrophages
Publicado: (1993)

AMPK contributes to autophagosome maturation and lysosomal fusion
por: Jang, Minsu, et al.
Publicado: (2018)

The Proteasome and the Delicate Balance between Destruction and Rescue
por: Glickman, Michael H, et al.
Publicado: (2004)

Lysosomal positioning diseases: beyond substrate storage
por: Scerra, Gianluca, et al.
Publicado: (2022)

Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway
por: Gain, Chandrima, et al.
Publicado: (2020)

Ubiquilin/Dsk2 promotes inclusion body formation and vacuole (lysosome)-mediated disposal of mutated huntingtin
por: Chuang, Kun-Han, et al.
Publicado: (2016)

Substrate selection by the proteasome during degradation of protein complexes
por: Prakash, Sumit, et al.
Publicado: (2008)

Conformational switching of the 26S proteasome enables substrate degradation
por: Matyskiela, Mary E., et al.
Publicado: (2013)

Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome
por: Yu, Houqing, et al.
Publicado: (2016)

Structural Insights into Substrate Recognition and Processing by the 20S Proteasome
por: Sahu, Indrajit, et al.
Publicado: (2021)

ATP-independent substrate recruitment to proteasomal degradation in mycobacteria
por: von Rosen, Tatjana, et al.
Publicado: (2023)

Financial inclusion and households’ choice of solid waste disposal in Ghana
por: Immurana, Mustapha, et al.
Publicado: (2022)

Role of adenosine in oligodendrocyte precursor maturation
por: Coppi, Elisabetta, et al.
Publicado: (2015)

Phosphorylation of Nicastrin by SGK1 Leads to Its Degradation through Lysosomal and Proteasomal Pathways
por: Mo, Jung-Soon, et al.
Publicado: (2012)

Down-Regulation of Desmosomes in Cultured Cells: The Roles of PKC, Microtubules and Lysosomal/Proteasomal Degradation
por: McHarg, Selina, et al.
Publicado: (2014)

Cullin 7 mediates proteasomal and lysosomal degradations of rat Eag1 potassium channels
por: Hsu, Po-Hao, et al.
Publicado: (2017)

Proteasome Inhibition Activates Autophagy-Lysosome Pathway Associated With TFEB Dephosphorylation and Nuclear Translocation
por: Li, Chunyan, et al.
Publicado: (2019)

Rab21 Protein Is Degraded by Both the Ubiquitin-Proteasome Pathway and the Autophagy-Lysosome Pathway
por: Liu, Pinduo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pqr7nqnotjpfjdfqethdkfu70a