Anti-Transforming Growth Factor ß Antibody Treatment Rescues Bone Loss and Prevents Breast Cancer Metastasis to Bone

Breast cancer often metastasizes to bone causing osteolytic bone resorption which releases active TGFβ. Because TGFβ favors progression of breast cancer metastasis to bone, we hypothesized that treatment using anti-TGFβ antibody may reduce tumor burden and rescue tumor-associated bone loss in metast...

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Detalles Bibliográficos
Autores principales: Biswas, Swati, Nyman, Jeffry S., Alvarez, JoAnn, Chakrabarti, Anwesa, Ayres, Austin, Sterling, Julie, Edwards, James, Rana, Tapasi, Johnson, Rachelle, Perrien, Daniel S., Lonning, Scott, Shyr, Yu, Matrisian, Lynn M., Mundy, Gregory R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214031/
https://www.ncbi.nlm.nih.gov/pubmed/22096521
http://dx.doi.org/10.1371/journal.pone.0027090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214031/
https://www.ncbi.nlm.nih.gov/pubmed/22096521
http://dx.doi.org/10.1371/journal.pone.0027090

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