Insufficiently Defined Genetic Background Confounds Phenotypes in Transgenic Studies As Exemplified by Malaria Infection in Tlr9 Knockout Mice

The use of genetically modified mice, i.e. transgenic as well as gene knockout (KO) and knock-in mice, has become an established tool to study gene function in many animal models for human diseases . However, a gene functions in a particular genomic context. This implies the importance of a well-def...

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Detalles Bibliográficos
Autores principales: Geurts, Nathalie, Martens, Erik, Verhenne, Sebastien, Lays, Natacha, Thijs, Greet, Magez, Stefan, Cauwe, Bénédicte, Li, Sandra, Heremans, Hubertine, Opdenakker, Ghislain, Van den Steen, Philippe E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214040/
https://www.ncbi.nlm.nih.gov/pubmed/22096530
http://dx.doi.org/10.1371/journal.pone.0027131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214040/
https://www.ncbi.nlm.nih.gov/pubmed/22096530
http://dx.doi.org/10.1371/journal.pone.0027131

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