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p21-Activated Kinase 1 (Pak1) Phosphorylates BAD Directly at Serine 111 In Vitro and Indirectly through Raf-1 at Serine 112

BACKGROUND: Cell survival depends on the balance between protective and apoptotic signals. When the balance of signals tips towards apoptosis, cells undergo programmed cell death. This balance has profound implications in diseases including cancer. Oncogenes and tumor suppressors are mutated to prom...

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Detalles Bibliográficos
Autores principales: Ye, Diana Z., Jin, Shenghao, Zhuo, Ya, Field, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214075/
https://www.ncbi.nlm.nih.gov/pubmed/22096607
http://dx.doi.org/10.1371/journal.pone.0027637