Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

Repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) requires resection of 5′-termini to generate 3′-single-strand DNA tails(1). Key components of this reaction are Exonuclease 1 and the bifunctional endo/exonuclease, Mre11(2-4). Mre11 endonuclease activity is critical when DSB...

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Detalles Bibliográficos
Autores principales: Garcia, Valerie, Phelps, Sarah E. L., Gray, Stephen, Neale, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214165/
https://www.ncbi.nlm.nih.gov/pubmed/22002605
http://dx.doi.org/10.1038/nature10515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214165/
https://www.ncbi.nlm.nih.gov/pubmed/22002605
http://dx.doi.org/10.1038/nature10515

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