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Probing the Limits of Aptamer Affinity with a Microfluidic SELEX Platform
Nucleic acid-based aptamers offer many potential advantages relative to antibodies and other protein-based affinity reagents, including facile chemical synthesis, reversible folding, improved thermal stability and lower cost. However, their selection requires significant time and resources and selec...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215713/ https://www.ncbi.nlm.nih.gov/pubmed/22110600 http://dx.doi.org/10.1371/journal.pone.0027051 |