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The docking protein p130Cas regulates cell sensitivity to proteasome inhibition

BACKGROUND: The focal adhesion protein p130Cas (Cas) activates multiple intracellular signaling pathways upon integrin or growth factor receptor ligation. Full-length Cas frequently promotes cell survival and migration, while its C-terminal fragment (Cas-CT) produced upon intracellular proteolysis i...

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Detalles Bibliográficos
Autores principales: Zhao, Ming, Vuori, Kristiina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215977/
https://www.ncbi.nlm.nih.gov/pubmed/22034875
http://dx.doi.org/10.1186/1741-7007-9-73