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The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

BACKGROUND: β-Amyloid (Aβ) plays a central role in Alzheimer's disease (AD) pathogenesis. Neurons are major sources of Aβ in the brain. However, astrocytes outnumber neurons by at least five-fold. Thus, even a small level of astrocytic Aβ production could make a significant contribution to Aβ b...

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Detalles Bibliográficos
Autores principales:	Zhao, Jie, O'Connor, Tracy, Vassar, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216000/ https://www.ncbi.nlm.nih.gov/pubmed/22047170 http://dx.doi.org/10.1186/1742-2094-8-150

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