Inhibition of Aldose Reductase Activates Hepatic Peroxisome Proliferator-Activated Receptor-α and Ameliorates Hepatosteatosis in Diabetic db/db Mice

We previously demonstrated in streptozotocin-induced diabetic mice that deficiency or inhibition of aldose reductase (AR) caused significant dephosphorylation of hepatic transcriptional factor PPARα, leading to its activation and significant reductions in serum lipid levels. Herein, we report that i...

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Detalles Bibliográficos
Autores principales: Qiu, Longxin, Lin, Jianhui, Xu, Fangui, Gao, Yuehong, Zhang, Cuilin, Liu, Ying, Luo, Yu, Yang, James Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216305/
https://www.ncbi.nlm.nih.gov/pubmed/22110479
http://dx.doi.org/10.1155/2012/789730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216305/
https://www.ncbi.nlm.nih.gov/pubmed/22110479
http://dx.doi.org/10.1155/2012/789730

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