Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum

The human malaria parasite Plasmodium falciparum is responsible for the deaths of more than a million people each year. Fosmidomycin has been proven to be efficient in the treatment of P. falciparum malaria by inhibiting 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), an enzyme of the non-mev...

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Detalles Bibliográficos
Autores principales: Umeda, Tomonobu, Tanaka, Nobutada, Kusakabe, Yoshio, Nakanishi, Masayuki, Kitade, Yukio, Nakamura, Kazuo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216497/
https://www.ncbi.nlm.nih.gov/pubmed/22355528
http://dx.doi.org/10.1038/srep00009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216497/
https://www.ncbi.nlm.nih.gov/pubmed/22355528
http://dx.doi.org/10.1038/srep00009

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