Disruption of plasmepsin-4 and merozoites surface protein-7 genes in Plasmodium berghei induces combined virulence-attenuated phenotype

Blood stage malaria parasites causing a mild and self limited infection in mice have been obtained with either radiation or chemical mutagenesis showing the possibility of developing an attenuated malaria vaccine. Targeted disruption of plasmepsin-4 (pm4) or the merozoite surface protein-7 (msp7) ge...

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Detalles Bibliográficos
Autores principales: Spaccapelo, Roberta, Aime, Elena, Caterbi, Sara, Arcidiacono, Paola, Capuccini, Barbara, Di Cristina, Manlio, Dottorini, Tania, Rende, Mario, Bistoni, Francesco, Crisanti, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216526/
https://www.ncbi.nlm.nih.gov/pubmed/22355558
http://dx.doi.org/10.1038/srep00039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216526/
https://www.ncbi.nlm.nih.gov/pubmed/22355558
http://dx.doi.org/10.1038/srep00039

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