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Next generation sequencing has lower sequence coverage and poorer SNP-detection capability in the regulatory regions
The rapid development of next generation sequencing (NGS) technology provides a new chance to extend the scale and resolution of genomic research. How to efficiently map millions of short reads to the reference genome and how to make accurate SNP calls are two major challenges in taking full advanta...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216542/ https://www.ncbi.nlm.nih.gov/pubmed/22355574 http://dx.doi.org/10.1038/srep00055 |