Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness

Crk-associated substrate (CAS) is a major tyrosine-phosphorylated protein in cells transformed by v-crk and v-src oncogenes and plays an important role in invasiveness of Src-transformed cells. A novel phosphorylation site on CAS, Tyr-12 (Y12) within the ligand-binding hydrophobic pocket of the CAS...

Descripción completa

Detalles Bibliográficos
Autores principales: Janoštiak, Radoslav, Tolde, Ondřej, Brůhová, Zuzana, Novotný , Marian, Hanks, Steven K., Rösel, Daniel, Brábek, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216652/
https://www.ncbi.nlm.nih.gov/pubmed/21937722
http://dx.doi.org/10.1091/mbc.E11-03-0207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216652/
https://www.ncbi.nlm.nih.gov/pubmed/21937722
http://dx.doi.org/10.1091/mbc.E11-03-0207

Ejemplares similares