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β3 Integrin–EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells

Active RhoA localizes to plasma membrane, where it stimulates formation of focal adhesions and stress fibers. RhoA activity is inhibited by p190RhoGAP following integrin-mediated cell attachment to allow sampling of new adhesive environments. p190RhoGAP is itself activated by Src-dependent tyrosine...

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Detalles Bibliográficos
Autores principales: Balanis, Nikolas, Yoshigi, Masaaki, Wendt, Michael K., Schiemann, William P., Carlin, Cathleen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216655/
https://www.ncbi.nlm.nih.gov/pubmed/21937717
http://dx.doi.org/10.1091/mbc.E10-08-0700