Cargando…

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress

Disruptions of the endoplasmic reticulum (ER) that perturb protein folding cause ER stress and elicit an unfolded protein response (UPR) that involves translational and transcriptional changes in gene expression aimed at expanding the ER processing capacity and alleviating cellular injury. Three ER...

Descripción completa

Detalles Bibliográficos
Autores principales:	Teske, Brian F., Wek, Sheree A., Bunpo, Piyawan, Cundiff, Judy K., McClintick, Jeanette N., Anthony, Tracy G., Wek, Ronald C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216664/ https://www.ncbi.nlm.nih.gov/pubmed/21917591 http://dx.doi.org/10.1091/mbc.E11-06-0510

Ejemplares similares

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis
por: Teske, Brian F., et al.
Publicado: (2013)

Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα
por: Baird, Thomas D., et al.
Publicado: (2014)

Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2
por: Saito, Atsushi, et al.
Publicado: (2011)

Dynamic changes in complexes of IRE1α, PERK, and ATF6α during endoplasmic reticulum stress
por: Sundaram, Arunkumar, et al.
Publicado: (2018)

Fuziline alleviates isoproterenol‐induced myocardial injury by inhibiting ROS‐triggered endoplasmic reticulum stress via PERK/eIF2α/ATF4/Chop pathway
por: Fan, Cai‐lian, et al.
Publicado: (2019)

Endoplasmic Reticulum Stress PERK-ATF4-CHOP Pathway Is Associated with Hypothalamic Neuronal Injury in Different Durations of Stress in Rats
por: Yi, Shanyong, et al.
Publicado: (2017)

CPNE1 regulates myogenesis through the PERK-eIF2α pathway mediated by endoplasmic reticulum stress
por: Chen, Lin, et al.
Publicado: (2022)

Endoplasmic Reticulum Stress-Activated PERK-eIF2α-ATF4 Signaling Pathway is Involved in the Ameliorative Effects of Ginseng Polysaccharides against Cisplatin-Induced Nephrotoxicity in Mice
por: Wei, Xiao-meng, et al.
Publicado: (2021)

PCV2 and PRV Coinfection Induces Endoplasmic Reticulum Stress via PERK-eIF2α-ATF4-CHOP and IRE1-XBP1-EDEM Pathways
por: Chen, Si, et al.
Publicado: (2022)

Endoplasmic reticulum stress inhibits AR expression via the PERK/eIF2α/ATF4 pathway in luminal androgen receptor triple-negative breast cancer and prostate cancer
por: Li, Xiaoli, et al.
Publicado: (2022)

CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis
por: Willy, Jeffrey A., et al.
Publicado: (2015)

Endoplasmic reticulum stress pathway PERK‐eIF2α confers radioresistance in oropharyngeal carcinoma by activating NF‐κB
por: Qiao, Qiao, et al.
Publicado: (2017)

Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulum
por: McQuiston, Alexander, et al.
Publicado: (2017)

Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α
por: Md Nesran, Zarith Nameyrra, et al.
Publicado: (2019)

Endoplasmic Reticulum Stress Mediates Radiation-Induced Autophagy via PERK-eIF2α in Caspase-3/7 Deficient Cells
por: Kim, Kwang Woon, et al.
Publicado: (2010)

Valdecoxib Protects against Cell Apoptosis Induced by Endoplasmic Reticulum Stress via the Inhibition of PERK-ATF4-CHOP Pathway in Experimental Glaucoma
por: Gao, Zhaolin, et al.
Publicado: (2022)

Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
por: Pathak, Trayambak, et al.
Publicado: (2023)

Geraniol-Mediated Suppression of Endoplasmic Reticulum Stress Protects against Cerebral Ischemia–Reperfusion Injury via the PERK-ATF4-CHOP Pathway
por: Wu, Yu, et al.
Publicado: (2022)

PERK/EIF2AK3 integrates endoplasmic reticulum stress-induced apoptosis, oxidative stress and autophagy responses in immortalised retinal pigment epithelial cells
por: Saptarshi, Neil, et al.
Publicado: (2022)

PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy
por: Salaroglio, Iris C., et al.
Publicado: (2017)

Endoplasmic Reticulum Stress Is Involved in Stress-Induced Hypothalamic Neuronal Injury in Rats via the PERK-ATF4-CHOP and IRE1-ASK1-JNK Pathways
por: Yi, Shanyong, et al.
Publicado: (2019)

OTUB1 facilitates bladder cancer progression by stabilizing ATF6 in response to endoplasmic reticulum stress
por: Zhang, Hui‐Hui, et al.
Publicado: (2021)

Translational repression protects human keratinocytes from UVB-induced apoptosis through a discordant eIF2 kinase stress response
por: Collier, Ann E., et al.
Publicado: (2015)

Disease-associated mutations in a bifunctional aminoacyl-tRNA synthetase gene elicit the integrated stress response
por: Jin, Danni, et al.
Publicado: (2021)

PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress
por: Romine, Isabelle C., et al.
Publicado: (2019)

Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis
por: Dias-Teixeira, Karina Luiza, et al.
Publicado: (2017)

Endoplasmic reticulum stress eIF2α–ATF4 pathway-mediated cyclooxygenase-2 induction regulates cadmium-induced autophagy in kidney
por: Luo, B, et al.
Publicado: (2016)

DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression
por: Adjibade, Pauline, et al.
Publicado: (2017)

Oxidized phospholipids facilitate calcific aortic valve disease by elevating ATF4 through the PERK/eIF2α axis
por: Zhu, Xiaohua, et al.
Publicado: (2023)

Endoplasmic Reticulum Stress Mediated MDRV p10.8 Protein-Induced Cell Cycle Arrest and Apoptosis Through the PERK/eIF2α Pathway
por: Wang, Quanxi, et al.
Publicado: (2018)

Methamphetamine-mediated endoplasmic reticulum (ER) stress induces type-1 programmed cell death in astrocytes via ATF6, IRE1α and PERK pathways
por: Shah, Ankit, et al.
Publicado: (2016)

Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling
por: Carrara, Marta, et al.
Publicado: (2015)

Ciclopirox activates PERK-dependent endoplasmic reticulum stress to drive cell death in colorectal cancer
por: Qi, Jianjun, et al.
Publicado: (2020)

Manganese activates autophagy to alleviate endoplasmic reticulum stress–induced apoptosis via PERK pathway
por: Liu, Chang, et al.
Publicado: (2019)

Endoplasmic reticulum stress-mediated autophagy contributes to 5-ethylamino-9-diethylaminobenzo[a]phenoselenazinium-mediated photodynamic therapy via the PERK–eIF2α pathway
por: Chen, Jing, et al.
Publicado: (2018)

ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress
por: Wan, Xiao-shan, et al.
Publicado: (2014)

ATF3 regulates SPHK1 in cardiomyocyte injury via endoplasmic reticulum stress
por: Chen, Huiling, et al.
Publicado: (2023)

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4
por: Ogbechi, Joy, et al.
Publicado: (2018)

Ginsenoside Rg1 regulates autophagy and endoplasmic reticulum stress via the AMPK/mTOR and PERK/ATF4/CHOP pathways to alleviate alcohol-induced myocardial injury
por: Tian, Ge, et al.
Publicado: (2023)

Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver
por: Fusakio, Michael E., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_7f0d9furk04af25gs958jm74mk