Cargando…

Altered Islet Composition and Disproportionate Loss of Large Islets in Patients with Type 2 Diabetes

Human islets exhibit distinct islet architecture with intermingled alpha- and beta-cells particularly in large islets. In this study, we quantitatively examined pathological changes of the pancreas in patients with type 2 diabetes (T2D). Specifically, we tested a hypothesis that changes in endocrine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kilimnik, German, Zhao, Billy, Jo, Junghyo, Periwal, Vipul, Witkowski, Piotr, Misawa, Ryosuke, Hara, Manami
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216964/ https://www.ncbi.nlm.nih.gov/pubmed/22102895 http://dx.doi.org/10.1371/journal.pone.0027445

Ejemplares similares

Islet Formation during the Neonatal Development in Mice
por: Miller, Kevin, et al.
Publicado: (2009)

A Conserved Rule for Pancreatic Islet Organization
por: Hoang, Danh-Tai, et al.
Publicado: (2014)

Regional Differences in Islet Distribution in the Human Pancreas - Preferential Beta-Cell Loss in the Head Region in Patients with Type 2 Diabetes
por: Wang, Xiaojun, et al.
Publicado: (2013)

Geometric and topological characterization of the cytoarchitecture of islets of Langerhans
por: Aggarwal, Manu, et al.
Publicado: (2023)

The Beta Cell in Its Cluster: Stochastic Graphs of Beta Cell Connectivity in the Islets of Langerhans
por: Striegel, Deborah A., et al.
Publicado: (2015)

Design Principles of Pancreatic Islets: Glucose-Dependent Coordination of Hormone Pulses
por: Hoang, Danh-Tai, et al.
Publicado: (2016)

Quantitative dynamics of adipose cells
por: Jo, Junghyo, et al.
Publicado: (2012)

Insulin modulates the frequency of Ca(2+) oscillations in mouse pancreatic islets
por: Lee, Boah, et al.
Publicado: (2017)

In Vivo and In Situ Approach to Study Islet Microcirculation: A Mini-Review
por: Dybala, Michael P., et al.
Publicado: (2021)

Validation of a New North American Islet Donor Score for Donor Pancreas Selection and Successful Islet Isolation in a Medium-Volume Islet Transplant Center
por: Gołębiewska, Justyna E., et al.
Publicado: (2018)

The loss of pancreatic islet NADPH oxidase (NOX)2 improves islet transplantation
por: Wrublewsky, Selina, et al.
Publicado: (2022)

Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation
por: Miki, Atsushi, et al.
Publicado: (2018)

Phase modulation of insulin pulses enhances glucose regulation and enables inter-islet synchronization
por: Lee, Boah, et al.
Publicado: (2017)

Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus
por: Anteby, Roi, et al.
Publicado: (2021)

Small Islets Transplantation Superiority to Large Ones: Implications from Islet Microcirculation and Revascularization
por: Li, Wenjuan, et al.
Publicado: (2014)

Preparatory studies of composite mesenchymal stem cell islets for application in intraportal islet transplantation
por: Duprez, Ida Rasmusson, et al.
Publicado: (2011)

Altered Islet Morphology but Normal Islet Secretory Function In Vitro in a Mouse Model with Microvascular Alterations in the Pancreas
por: Kostromina, Elena, et al.
Publicado: (2013)

Insulin expression in β cells is reduced within islets before islet loss in diabetic cats
por: Bergomi, V., et al.
Publicado: (2022)

Cdk4 Regulates Recruitment of Quiescent β-Cells and Ductal Epithelial Progenitors to Reconstitute β-Cell Mass
por: Lee, Ji-Hyeon, et al.
Publicado: (2010)

Australia and New Zealand Islet and Pancreas Transplant Registry Annual Report 2018—Islet Donations, Islet Isolations, and Islet Transplants
por: Webster, Angela C., et al.
Publicado: (2019)

Australia and New Zealand Islet and Pancreas Transplant Registry Annual Report 2019: Islet Donations, Islet Isolations, and Islet Transplants
por: Webster, Angela C., et al.
Publicado: (2020)

Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999–2010
por: Balamurugan, A N, et al.
Publicado: (2014)

“Old School” Islet Purification Based on the Unit Gravity Sedimentation as a Rescue Technique for Intraportal Islet Transplantation—A Case Report
por: Gołębiewska, Justyna E., et al.
Publicado: (2020)

Donor Islet Endothelial Cells in Pancreatic Islet Revascularization
por: Nyqvist, Daniel, et al.
Publicado: (2011)

IsletLab: an application to reconstruct and analyze islet architectures
por: Félix-Martínez, Gerardo J.
Publicado: (2021)

Small human islets comprised of more β-cells with higher insulin content than large islets
por: Farhat, Bilal, et al.
Publicado: (2013)

Effect of the Diabetic State on Islet Engraftment and Function in a Large Animal Model of Islet–Kidney Transplantation
por: Vallabhajosyula, Prashanth, et al.
Publicado: (2018)

Advances and Challenges in Islet Transplantation: Islet Procurement Rates and Lessons Learned from Suboptimal Islet Transplantation
por: Plesner, Annette, et al.
Publicado: (2011)

Islet biology
por: Lickert, Heiko, et al.
Publicado: (2017)

Rotational Transport of Islets: The Best Way for Islets to Get around?
por: Oberhuber, Rupert, et al.
Publicado: (2013)

Islet Gene View—a tool to facilitate islet research
por: Asplund, Olof, et al.
Publicado: (2022)

Formation of Composite Endothelial Cell–Mesenchymal Stem Cell Islets: A Novel Approach to Promote Islet Revascularization
por: Johansson, Ulrika, et al.
Publicado: (2008)

Beta-cell hubs maintain Ca(2+) oscillations in human and mouse islet simulations
por: Lei, Chon-Lok, et al.
Publicado: (2018)

Stereological analyses of the whole human pancreas
por: Poudel, Ananta, et al.
Publicado: (2016)

Insulin Resistance Alters Islet Morphology in Nondiabetic Humans
por: Mezza, Teresa, et al.
Publicado: (2014)

MicroRNA Expression in Alpha and Beta Cells of Human Pancreatic Islets
por: Klein, Dagmar, et al.
Publicado: (2013)

Markedly Decreased Blood Perfusion of Pancreatic Islets Transplanted Intraportally Into the Liver: Disruption of Islet Integrity Necessary for Islet Revascularization
por: Henriksnäs, Johanna, et al.
Publicado: (2012)

Total Pancreatectomy with Islet Autotransplantation for the Ampullary Cancer. A Case Report
por: Savari, Omid, et al.
Publicado: (2017)

Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation
por: Huurman, Volkert A. L., et al.
Publicado: (2008)

Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes
por: Campbell-Thompson, Martha, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_r9saed4qcgsopjea873ac4c3ih