Cargando…

Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity

BACKGROUND: The 90-kDa ribosomal S6 kinase (Rsk) family is involved in cell survival. Rsk activation is regulated by sequential phosphorylations controlled by extracellular signal-regulated kinase (ERK) 1/2 and 3-phosphoinositide-dependent protein kinase 1 (PDK1). Altered ERK1/2 and PDK1 phosphoryla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xifró, Xavier, Anglada-Huguet, Marta, Rué, Laura, Saavedra, Ana, Pérez-Navarro, Esther, Alberch, Jordi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217046/ https://www.ncbi.nlm.nih.gov/pubmed/22041125 http://dx.doi.org/10.1186/1750-1326-6-74

Ejemplares similares

Cloning and promoter analysis of palladin 90-kDa, 140-kDa, and 200-kDa isoforms involved in skeletal muscle cell maturation
por: Ouali, Boimpoundi Eunice Flavie, et al.
Publicado: (2020)

Mutant Huntingtin induces activation of the Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3)
por: Sassone, J, et al.
Publicado: (2010)

The p90 Ribosomal S6 Kinase (RSK) Is a Mediator of Smooth Muscle Contractility
por: Artamonov, Mykhaylo, et al.
Publicado: (2013)

Hypoxia-Induced Invadopodia Formation Involves Activation of NHE-1 by the p90 Ribosomal S6 Kinase (p90RSK)
por: Lucien, Fabrice, et al.
Publicado: (2011)

Role of p90RSK in Kidney and Other Diseases
por: Lin, Ling, et al.
Publicado: (2019)

Data on physicochemical properties of LPEI 25 kDa, PEI“Max” 40 kDa and PEIpro™
por: Delafosse, Laurence, et al.
Publicado: (2016)

Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease
por: Miguez, Andrés, et al.
Publicado: (2023)

Heat Shock Proteins 90 kDa: Immunomodulators and Adjuvants in Vaccine Design Against Infectious Diseases
por: Corigliano, Mariana G., et al.
Publicado: (2021)

In Vitro Inhibition of Angiogenesis by Antibodies Directed against the 37kDa/67kDa Laminin Receptor
por: Khusal, Raksha, et al.
Publicado: (2013)

Radiation therapy induces immunosenescence mediated by p90RSK
por: Imanishi, Masaki, et al.
Publicado: (2022)

p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration
por: Samson, Shiela C., et al.
Publicado: (2019)

The ribosomal S6 kinase 2 (RSK2)–SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling
por: Lopez, Jocelyne, et al.
Publicado: (2023)

Expression of the 60 kDa and 71 kDa heat shock proteins and presence of antibodies against the 71 kDa heat shock protein in pediatric patients with immune thrombocytopenic purpura
por: Xiao, Chengfeng, et al.
Publicado: (2004)

The 37kDa/67kDa Laminin Receptor acts as a receptor for Aβ(42) internalization
por: Da Costa Dias, Bianca, et al.
Publicado: (2014)

Knock-Down of the 37kDa/67kDa Laminin Receptor LRP/LR Impedes Telomerase Activity
por: Naidoo, Kerrilyn, et al.
Publicado: (2015)

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity
por: Luo, Shouqing, et al.
Publicado: (2005)

Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease
por: Eshraghi, Mehdi, et al.
Publicado: (2021)

p90Rsk is not involved in cytostatic factor arrest in mouse oocytes
por: Dumont, Julien, et al.
Publicado: (2005)

Enhanced gene transfection efficiency by low-dose 25 kDa polyethylenimine by the assistance of 1.8 kDa polyethylenimine
por: Zhang, Hui, et al.
Publicado: (2018)

Substituted pteridinones, pyrimidines, pyrrolopyrimidines, and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors: Pharmacophore modeling data
por: Warfield, Becka M., et al.
Publicado: (2021)

An internal ribosome entry site element directs the synthesis of the 80 kDa isoforms of protein 4.1R
por: Lospitao, Eva, et al.
Publicado: (2008)

HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19
por: He, Wen-Tian, et al.
Publicado: (2017)

Phosphorylation of Mutant Huntingtin at Serine 116 Modulates Neuronal Toxicity
por: Watkin, Erin E., et al.
Publicado: (2014)

RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit
por: Cerezo, Emilie L., et al.
Publicado: (2021)

The 18 kDa Translocator Protein, Microglia and Neuroinflammation
por: Liu, Guo‐Jun, et al.
Publicado: (2014)

Monodisperse 130 kDa and 260 kDa Recombinant Human Hemoglobin Polymers as Scaffolds for Protein Engineering of Hemoglobin-Based Oxygen Carriers
por: Marquardt, David A., et al.
Publicado: (2012)

The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21(WAF1/CIP1)
por: Neise, D, et al.
Publicado: (2013)

Novel Epigallocatechin-3-Gallate (EGCG) Derivative as a New Therapeutic Strategy for Reducing Neuropathic Pain after Chronic Constriction Nerve Injury in Mice
por: Xifró, Xavier, et al.
Publicado: (2015)

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Protects Striatal Cells and Improves Motor Function in Huntington’s Disease Models: Role of PAC1 Receptor
por: Solés-Tarrés, Irene, et al.
Publicado: (2022)

MALDI-TOF High Mass Calibration up to 200 kDa Using Human Recombinant 16 kDa Protein Histidine Phosphatase Aggregates
por: Ludwig, Katrin, et al.
Publicado: (2011)

Reverse mutants of the catalytic 19 kDa mutant protein (nanoKAZ/nanoLuc) from Oplophorus luciferase with coelenterazine as preferred substrate
por: Inouye, Satoshi, et al.
Publicado: (2022)

An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity
por: Cisbani, G, et al.
Publicado: (2012)

Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide
por: Song, Haikun, et al.
Publicado: (2022)

Antimicrobial Properties of an Immunomodulator - 15 kDa Human Granulysin
por: Wei, Hung-Mu, et al.
Publicado: (2016)

Structural Analysis of the 42 kDa Parvulin of Trypanosoma brucei
por: Rehic, Edisa, et al.
Publicado: (2019)

The Role of Heat Shock Protein 70 kDa in Asthma
por: Shevchenko, Marina, et al.
Publicado: (2021)

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin
por: Damiano, Maria, et al.
Publicado: (2013)

A selenosemicarbazone complex with copper efficiently down-regulates the 90-kDa heat shock protein HSP90AA1 and its client proteins in cancer cells
por: Shen, Hongtao, et al.
Publicado: (2014)

Normal Aging Modulates the Neurotoxicity of Mutant Huntingtin
por: Diguet, Elsa, et al.
Publicado: (2009)

Mutant huntingtin in the hypothalamus causes metabolic dysfunction
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_57nfm5323eho3ku0lf0sekpmfi