Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway

Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic at inflammatory sites, the mechanisms by which cells respond to acidosis are not well understood. Using molecular, cellular and biochemical approaches, we demonstrate that...

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Detalles Bibliográficos
Autores principales: Chen, Aishe, Dong, Lixue, Leffler, Nancy R., Asch, Adam S., Witte, Owen N., Yang, Li V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217975/
https://www.ncbi.nlm.nih.gov/pubmed/22110680
http://dx.doi.org/10.1371/journal.pone.0027586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217975/
https://www.ncbi.nlm.nih.gov/pubmed/22110680
http://dx.doi.org/10.1371/journal.pone.0027586

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