FDA-Approved Drugs that Protect Mammalian Neurons from Glucose Toxicity Slow Aging Dependent on Cbp and Protect Against Proteotoxicity

Screening a library of drugs with known safety profiles in humans yielded 30 drugs that reliably protected mammalian neurons against glucose toxicity. Subsequent screening demonstrated that 6 of these 30 drugs increase lifespan in C. elegans: caffeine, ciclopirox olamine, tannic acid, acetaminophen,...

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Detalles Bibliográficos
Autores principales: Lublin, Alex, Isoda, Fumiko, Patel, Harshil, Yen, Kelvin, Nguyen, Linda, Hajje, Daher, Schwartz, Marc, Mobbs, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218048/
https://www.ncbi.nlm.nih.gov/pubmed/22114686
http://dx.doi.org/10.1371/journal.pone.0027762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218048/
https://www.ncbi.nlm.nih.gov/pubmed/22114686
http://dx.doi.org/10.1371/journal.pone.0027762

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