MD simulation and experimental evidence for Mg(2+) binding at the B site in human AP endonuclease 1

Apurinic/apyrimidinic endonuclease 1 (APE1), a central enzyme in the base excision repair pathway, cleaves damaged DNA in Mg(2+) dependent reaction. Despite characterization of nine X-ray crystallographic structures of human APE1, in some cases, bound to various metal ions and substrate/product, the...

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Detalles Bibliográficos
Autores principales: Oezguen, Numan, Mantha, Anil K, Izumi, Tadahide, Schein, Catherine H, Mitra, Sankar, Braun, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2011
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218521/
https://www.ncbi.nlm.nih.gov/pubmed/22102776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218521/
https://www.ncbi.nlm.nih.gov/pubmed/22102776

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