Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity

Mithramycin (MTM), a natural product of soil bacteria from the Streptomyces genus, displays potent anticancer activity but has been limited clinically by severe side effects and toxicities. Engineering of the MTM biosynthetic pathway has produced the 3-side-chain-modified analogs MTM SK (SK) and MTM...

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Detalles Bibliográficos
Autores principales: Scott, Daniel, Rohr, Jürgen, Bae, Younsoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218587/
https://www.ncbi.nlm.nih.gov/pubmed/22114504
http://dx.doi.org/10.2147/IJN.S25427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218587/
https://www.ncbi.nlm.nih.gov/pubmed/22114504
http://dx.doi.org/10.2147/IJN.S25427

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