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Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity
Mithramycin (MTM), a natural product of soil bacteria from the Streptomyces genus, displays potent anticancer activity but has been limited clinically by severe side effects and toxicities. Engineering of the MTM biosynthetic pathway has produced the 3-side-chain-modified analogs MTM SK (SK) and MTM...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove Medical Press
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218587/ https://www.ncbi.nlm.nih.gov/pubmed/22114504 http://dx.doi.org/10.2147/IJN.S25427 |