Somatic structural rearrangements in genetically engineered mouse mammary tumors

BACKGROUND: Here we present the first paired-end sequencing of tumors from genetically engineered mouse models of cancer to determine how faithfully these models recapitulate the landscape of somatic rearrangements found in human tumors. These were models of Trp53-mutated breast cancer, Brca1- and B...

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Detalles Bibliográficos
Autores principales: Varela, Ignacio, Klijn, Christiaan, Stephens, Phillip J, Mudie, Laura J, Stebbings, Lucy, Galappaththige, Danushka, van der Gulden, Hanneke, Schut, Eva, Klarenbeek, Sjoerd, Campbell, Peter J, Wessels, Lodewyk FA, Stratton, Michael R, Jonkers, Jos, Futreal, P Andrew, Adams, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218656/
https://www.ncbi.nlm.nih.gov/pubmed/20942901
http://dx.doi.org/10.1186/gb-2010-11-10-r100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218656/
https://www.ncbi.nlm.nih.gov/pubmed/20942901
http://dx.doi.org/10.1186/gb-2010-11-10-r100

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