Improved variant discovery through local re-alignment of short-read next-generation sequencing data using SRMA

A primary component of next-generation sequencing analysis is to align short reads to a reference genome, with each read aligned independently. However, reads that observe the same non-reference DNA sequence are highly correlated and can be used to better model the true variation in the target genom...

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Detalles Bibliográficos
Autores principales: Homer, Nils, Nelson, Stanley F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218665/
https://www.ncbi.nlm.nih.gov/pubmed/20932289
http://dx.doi.org/10.1186/gb-2010-11-10-r99

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218665/
https://www.ncbi.nlm.nih.gov/pubmed/20932289
http://dx.doi.org/10.1186/gb-2010-11-10-r99

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