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Substitution rate variation at human CpG sites correlates with non-CpG divergence, methylation level and GC content
BACKGROUND: A major goal in the study of molecular evolution is to unravel the mechanisms that induce variation in the germ line mutation rate and in the genome-wide mutation profile. The rate of germ line mutation is considerably higher for cytosines at CpG sites than for any other nucleotide in th...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218846/ https://www.ncbi.nlm.nih.gov/pubmed/21696599 http://dx.doi.org/10.1186/gb-2011-12-6-r58 |