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Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy
BACKGROUND: Chromosomal aneuploidy, that is to say the gain or loss of chromosomes, is the most common abnormality in cancer. While certain aberrations, most commonly translocations, are known to be strongly associated with specific cancers and contribute to their formation, most aberrations appear...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218849/ https://www.ncbi.nlm.nih.gov/pubmed/21714908 http://dx.doi.org/10.1186/gb-2011-12-6-r61 |
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author | Ozery-Flato, Michal Linhart, Chaim Trakhtenbrot, Luba Izraeli, Shai Shamir, Ron |
author_facet | Ozery-Flato, Michal Linhart, Chaim Trakhtenbrot, Luba Izraeli, Shai Shamir, Ron |
author_sort | Ozery-Flato, Michal |
collection | PubMed |
description | BACKGROUND: Chromosomal aneuploidy, that is to say the gain or loss of chromosomes, is the most common abnormality in cancer. While certain aberrations, most commonly translocations, are known to be strongly associated with specific cancers and contribute to their formation, most aberrations appear to be non-specific and arbitrary, and do not have a clear effect. The understanding of chromosomal aneuploidy and its role in tumorigenesis is a fundamental open problem in cancer biology. RESULTS: We report on a systematic study of the characteristics of chromosomal aberrations in cancers, using over 15,000 karyotypes and 62 cancer classes in the Mitelman Database. Remarkably, we discovered a very high co-occurrence rate of chromosome gains with other chromosome gains, and of losses with losses. Gains and losses rarely show significant co-occurrence. This finding was consistent across cancer classes and was confirmed on an independent comparative genomic hybridization dataset of cancer samples. The results of our analysis are available for further investigation via an accompanying website. CONCLUSIONS: The broad generality and the intricate characteristics of the dichotomy of aneuploidy, ranging across numerous tumor classes, are revealed here rigorously for the first time using statistical analyses of large-scale datasets. Our finding suggests that aneuploid cancer cells may use extra chromosome gain or loss events to restore a balance in their altered protein ratios, needed for maintaining their cellular fitness. |
format | Online Article Text |
id | pubmed-3218849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32188492011-11-18 Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy Ozery-Flato, Michal Linhart, Chaim Trakhtenbrot, Luba Izraeli, Shai Shamir, Ron Genome Biol Research BACKGROUND: Chromosomal aneuploidy, that is to say the gain or loss of chromosomes, is the most common abnormality in cancer. While certain aberrations, most commonly translocations, are known to be strongly associated with specific cancers and contribute to their formation, most aberrations appear to be non-specific and arbitrary, and do not have a clear effect. The understanding of chromosomal aneuploidy and its role in tumorigenesis is a fundamental open problem in cancer biology. RESULTS: We report on a systematic study of the characteristics of chromosomal aberrations in cancers, using over 15,000 karyotypes and 62 cancer classes in the Mitelman Database. Remarkably, we discovered a very high co-occurrence rate of chromosome gains with other chromosome gains, and of losses with losses. Gains and losses rarely show significant co-occurrence. This finding was consistent across cancer classes and was confirmed on an independent comparative genomic hybridization dataset of cancer samples. The results of our analysis are available for further investigation via an accompanying website. CONCLUSIONS: The broad generality and the intricate characteristics of the dichotomy of aneuploidy, ranging across numerous tumor classes, are revealed here rigorously for the first time using statistical analyses of large-scale datasets. Our finding suggests that aneuploid cancer cells may use extra chromosome gain or loss events to restore a balance in their altered protein ratios, needed for maintaining their cellular fitness. BioMed Central 2011 2011-06-29 /pmc/articles/PMC3218849/ /pubmed/21714908 http://dx.doi.org/10.1186/gb-2011-12-6-r61 Text en Copyright ©2011 Ozery-Flato et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Ozery-Flato, Michal Linhart, Chaim Trakhtenbrot, Luba Izraeli, Shai Shamir, Ron Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy |
title | Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy |
title_full | Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy |
title_fullStr | Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy |
title_full_unstemmed | Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy |
title_short | Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy |
title_sort | large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218849/ https://www.ncbi.nlm.nih.gov/pubmed/21714908 http://dx.doi.org/10.1186/gb-2011-12-6-r61 |
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