EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells

Members of the Polycomb-group (PcG) family of proteins, including EZH2 (enhancer of zeste homolog 2), are involved in establishing epigenetic silencing of developmental genes in adult and embryonic stem cells, and their deregulation has been implicated in cancer. In a recent report, EZH2-mediated ep...

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Detalles Bibliográficos
Autores principales: Stefansson, Olafur Andri, Esteller, Manel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218929/
https://www.ncbi.nlm.nih.gov/pubmed/21672285
http://dx.doi.org/10.1186/bcr2871
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author Stefansson, Olafur Andri
Esteller, Manel
author_facet Stefansson, Olafur Andri
Esteller, Manel
author_sort Stefansson, Olafur Andri
collection PubMed
description Members of the Polycomb-group (PcG) family of proteins, including EZH2 (enhancer of zeste homolog 2), are involved in establishing epigenetic silencing of developmental genes in adult and embryonic stem cells, and their deregulation has been implicated in cancer. In a recent report, EZH2-mediated epigenetic repression of DNA damage repair in breast tumor initiating cells (BTICs) was identified as a mechanism that could promote expansion of BTICs, and may contribute to cancer progression.
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spelling pubmed-32189292011-11-25 EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells Stefansson, Olafur Andri Esteller, Manel Breast Cancer Res Viewpoint Members of the Polycomb-group (PcG) family of proteins, including EZH2 (enhancer of zeste homolog 2), are involved in establishing epigenetic silencing of developmental genes in adult and embryonic stem cells, and their deregulation has been implicated in cancer. In a recent report, EZH2-mediated epigenetic repression of DNA damage repair in breast tumor initiating cells (BTICs) was identified as a mechanism that could promote expansion of BTICs, and may contribute to cancer progression. BioMed Central 2011 2011-05-25 /pmc/articles/PMC3218929/ /pubmed/21672285 http://dx.doi.org/10.1186/bcr2871 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Viewpoint
Stefansson, Olafur Andri
Esteller, Manel
EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells
title EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells
title_full EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells
title_fullStr EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells
title_full_unstemmed EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells
title_short EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells
title_sort ezh2-mediated epigenetic repression of dna repair in promoting breast tumor initiating cells
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218929/
https://www.ncbi.nlm.nih.gov/pubmed/21672285
http://dx.doi.org/10.1186/bcr2871
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