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Notch signaling as a therapeutic target for breast cancer treatment?
Aberrant Notch signaling can induce mammary gland carcinoma in transgenic mice, and high expressions of Notch receptors and ligands have been linked to poor clinical outcomes in human patients with breast cancer. This suggests that inhibition of Notch signaling may be beneficial for breast cancer tr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218932/ https://www.ncbi.nlm.nih.gov/pubmed/21672271 http://dx.doi.org/10.1186/bcr2875 |
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author | Han, Jianxun Hendzel, Michael J Allalunis-Turner, Joan |
author_facet | Han, Jianxun Hendzel, Michael J Allalunis-Turner, Joan |
author_sort | Han, Jianxun |
collection | PubMed |
description | Aberrant Notch signaling can induce mammary gland carcinoma in transgenic mice, and high expressions of Notch receptors and ligands have been linked to poor clinical outcomes in human patients with breast cancer. This suggests that inhibition of Notch signaling may be beneficial for breast cancer treatment. In this review, we critically evaluate the evidence that supports or challenges the hypothesis that inhibition of Notch signaling would be advantageous in breast cancer management. We find that there are many remaining uncertainties that must be addressed experimentally if we are to exploit inhibition of Notch signaling as a treatment approach in breast cancer. Nonetheless, Notch inhibition, in combination with other therapies, is a promising avenue for future management of breast cancer. Furthermore, since aberrant Notch4 activity can induce mammary gland carcinoma in the absence of RBPjκ, a better understanding of the components of RBPjκ-independent oncogenic Notch signaling pathways and their contribution to Notch-induced tumorigenesis would facilitate the deployment of Notch inhibition strategies for effective treatment of breast cancer. |
format | Online Article Text |
id | pubmed-3218932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32189322011-12-01 Notch signaling as a therapeutic target for breast cancer treatment? Han, Jianxun Hendzel, Michael J Allalunis-Turner, Joan Breast Cancer Res Review Aberrant Notch signaling can induce mammary gland carcinoma in transgenic mice, and high expressions of Notch receptors and ligands have been linked to poor clinical outcomes in human patients with breast cancer. This suggests that inhibition of Notch signaling may be beneficial for breast cancer treatment. In this review, we critically evaluate the evidence that supports or challenges the hypothesis that inhibition of Notch signaling would be advantageous in breast cancer management. We find that there are many remaining uncertainties that must be addressed experimentally if we are to exploit inhibition of Notch signaling as a treatment approach in breast cancer. Nonetheless, Notch inhibition, in combination with other therapies, is a promising avenue for future management of breast cancer. Furthermore, since aberrant Notch4 activity can induce mammary gland carcinoma in the absence of RBPjκ, a better understanding of the components of RBPjκ-independent oncogenic Notch signaling pathways and their contribution to Notch-induced tumorigenesis would facilitate the deployment of Notch inhibition strategies for effective treatment of breast cancer. BioMed Central 2011 2011-05-31 /pmc/articles/PMC3218932/ /pubmed/21672271 http://dx.doi.org/10.1186/bcr2875 Text en Copyright ©2011 BioMed Central Ltd |
spellingShingle | Review Han, Jianxun Hendzel, Michael J Allalunis-Turner, Joan Notch signaling as a therapeutic target for breast cancer treatment? |
title | Notch signaling as a therapeutic target for breast cancer treatment? |
title_full | Notch signaling as a therapeutic target for breast cancer treatment? |
title_fullStr | Notch signaling as a therapeutic target for breast cancer treatment? |
title_full_unstemmed | Notch signaling as a therapeutic target for breast cancer treatment? |
title_short | Notch signaling as a therapeutic target for breast cancer treatment? |
title_sort | notch signaling as a therapeutic target for breast cancer treatment? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218932/ https://www.ncbi.nlm.nih.gov/pubmed/21672271 http://dx.doi.org/10.1186/bcr2875 |
work_keys_str_mv | AT hanjianxun notchsignalingasatherapeutictargetforbreastcancertreatment AT hendzelmichaelj notchsignalingasatherapeutictargetforbreastcancertreatment AT allalunisturnerjoan notchsignalingasatherapeutictargetforbreastcancertreatment |