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Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase

INTRODUCTION: The adhesion protein junctional adhesion molecule-A (JAM-A) regulates epithelial cell morphology and migration, and its over-expression has recently been linked with increased risk of metastasis in breast cancer patients. As cell migration is an early requirement for tumor metastasis,...

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Detalles Bibliográficos
Autores principales: McSherry, Elaine A, Brennan, Kieran, Hudson, Lance, Hill, Arnold DK, Hopkins, Ann M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219194/
https://www.ncbi.nlm.nih.gov/pubmed/21429211
http://dx.doi.org/10.1186/bcr2853