Second malignancies in breast cancer patients following radiotherapy: a study in Florence, Italy
INTRODUCTION: Patients diagnosed with breast cancer are often treated with surgery followed by radiation therapy. In this paper, we evaluate the effect that radiotherapy may have had on the subsequent risk of second malignancies, including the possible influences of age at treatment and menopausal s...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219201/ https://www.ncbi.nlm.nih.gov/pubmed/21463502 http://dx.doi.org/10.1186/bcr2860 |
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author | Zhang, Wei Becciolini, Aldo Biggeri, Annibale Pacini, Paolo Muirhead, Colin R |
author_facet | Zhang, Wei Becciolini, Aldo Biggeri, Annibale Pacini, Paolo Muirhead, Colin R |
author_sort | Zhang, Wei |
collection | PubMed |
description | INTRODUCTION: Patients diagnosed with breast cancer are often treated with surgery followed by radiation therapy. In this paper, we evaluate the effect that radiotherapy may have had on the subsequent risk of second malignancies, including the possible influences of age at treatment and menopausal status. METHODS: In order to evaluate the long-term consequences of radiotherapy, a cohort study was conducted based on clinical records for 5,248 women treated for breast cancer in Florence (Italy), with continuous follow-up from 1965 to 1994. The Cox proportional hazards model for ungrouped survival data was used to estimate the relative risk for second cancer after radiotherapy. RESULTS: This study indicated an increased relative risk of all second cancers combined following radiotherapy (1.22, 95% CI: 0.88 to 1.69). The increased relative risk appeared five or more years after radiotherapy and appeared to be highest amongst women treated after the menopause (1.61, 95% CI: 1.13 to 2.29). Increased relative risks were observed specifically for leukaemia (8.13, 95% CI: 0.96 to 69.1) and other solid cancers (1.84, 95% CI: 1.06 to 3.16), excluding contralateral breast cancer. For contralateral breast cancer, no raised relative risk was observed during the period more than five years after radiotherapy. CONCLUSIONS: The study indicated a raised risk of second malignancies associated with radiotherapy for breast cancer, particularly for women treated after the menopause. |
format | Online Article Text |
id | pubmed-3219201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32192012011-11-18 Second malignancies in breast cancer patients following radiotherapy: a study in Florence, Italy Zhang, Wei Becciolini, Aldo Biggeri, Annibale Pacini, Paolo Muirhead, Colin R Breast Cancer Res Research Article INTRODUCTION: Patients diagnosed with breast cancer are often treated with surgery followed by radiation therapy. In this paper, we evaluate the effect that radiotherapy may have had on the subsequent risk of second malignancies, including the possible influences of age at treatment and menopausal status. METHODS: In order to evaluate the long-term consequences of radiotherapy, a cohort study was conducted based on clinical records for 5,248 women treated for breast cancer in Florence (Italy), with continuous follow-up from 1965 to 1994. The Cox proportional hazards model for ungrouped survival data was used to estimate the relative risk for second cancer after radiotherapy. RESULTS: This study indicated an increased relative risk of all second cancers combined following radiotherapy (1.22, 95% CI: 0.88 to 1.69). The increased relative risk appeared five or more years after radiotherapy and appeared to be highest amongst women treated after the menopause (1.61, 95% CI: 1.13 to 2.29). Increased relative risks were observed specifically for leukaemia (8.13, 95% CI: 0.96 to 69.1) and other solid cancers (1.84, 95% CI: 1.06 to 3.16), excluding contralateral breast cancer. For contralateral breast cancer, no raised relative risk was observed during the period more than five years after radiotherapy. CONCLUSIONS: The study indicated a raised risk of second malignancies associated with radiotherapy for breast cancer, particularly for women treated after the menopause. BioMed Central 2011 2011-04-04 /pmc/articles/PMC3219201/ /pubmed/21463502 http://dx.doi.org/10.1186/bcr2860 Text en Copyright ©2011 Zhang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhang, Wei Becciolini, Aldo Biggeri, Annibale Pacini, Paolo Muirhead, Colin R Second malignancies in breast cancer patients following radiotherapy: a study in Florence, Italy |
title | Second malignancies in breast cancer patients following radiotherapy: a study in Florence, Italy |
title_full | Second malignancies in breast cancer patients following radiotherapy: a study in Florence, Italy |
title_fullStr | Second malignancies in breast cancer patients following radiotherapy: a study in Florence, Italy |
title_full_unstemmed | Second malignancies in breast cancer patients following radiotherapy: a study in Florence, Italy |
title_short | Second malignancies in breast cancer patients following radiotherapy: a study in Florence, Italy |
title_sort | second malignancies in breast cancer patients following radiotherapy: a study in florence, italy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219201/ https://www.ncbi.nlm.nih.gov/pubmed/21463502 http://dx.doi.org/10.1186/bcr2860 |
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