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Quantitative assays for the measurement of HER1-HER2 heterodimerization and phosphorylation in cell lines and breast tumors: applications for diagnostics and targeted drug mechanism of action
INTRODUCTION: Ligand-bound and phosphorylated ErbB/HER heterodimers are potent signaling forms of this receptor family, and quantitative measurements of these active receptors may be predictive of patient response to targeted therapies. Using VeraTag™ technology, we developed and characterized quant...
Autores principales: | DeFazio-Eli, Lisa, Strommen, Kristi, Dao-Pick, Trang, Parry, Gordon, Goodman, Laurie, Winslow, John |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219207/ https://www.ncbi.nlm.nih.gov/pubmed/21496232 http://dx.doi.org/10.1186/bcr2866 |
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