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Glucose deprivation in tuberous sclerosis complex-related tumors
BACKGROUND: Cancer cells possess unique metabolic phenotypes that are determined by their underlying oncogenic pathways. Activation of the PI3K/Akt/mTOR signaling cascade promotes glycolysis and leads to glucose-dependence in tumors. In particular, cells with constitutive mTORC1 activity secondary t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219560/ https://www.ncbi.nlm.nih.gov/pubmed/22018000 http://dx.doi.org/10.1186/2045-3701-1-34 |