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Crosstalk between ROS Homeostasis and Secondary Metabolism in S. natalensis ATCC 27448: Modulation of Pimaricin Production by Intracellular ROS
Streptomyces secondary metabolism is strongly affected by oxygen availability. The increased culture aeration enhances pimaricin production in S. natalensis, however the excess of O(2) consumption can lead to an intracellular ROS imbalance that is harmful to the cell. The adaptive physiological resp...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219662/ https://www.ncbi.nlm.nih.gov/pubmed/22114674 http://dx.doi.org/10.1371/journal.pone.0027472 |